F10 Binding parameters of $alpha;2-adrenoceptors are altered in essential hypertension
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Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors.
1 Atipamezole (4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole) was first introduced as a potent and specific alpha2-adrenoceptor antagonist, but in some tissues [3H]atipamezole identifies an additional population of binding sites, distinct from both classical alpha2-adrenoceptors and I1- and I2-imidazoline receptors identified with [3H]para-aminoclonidine or [3H]idazoxan. 2 In the present s...
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Agonist binding to alpha2-adrenoceptors is modulated by a number of factors such as Mg2+ and Na+ ions and by experimental manipulations which interfere with receptor-G-protein-coupling such as pertussis toxin pre-treatment or the presence of guanine nucleotides. Agonist binding assays may therefore offer an opportunity to make inferences, albeit indirect, about receptor states or conformations ...
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Presynaptic autoreceptors were discovered by six groups of researchers in 1971. The receptors of 1971 were autoreceptors regulating the release of noradrenaline, acetylcholine and GABA (Starke et al. 1989). The ®rst 10 years after 1971 yielded the basic evidence. Carlsson (1975) coined the term `autoreceptors', receptors `sensitive to the neuron's own transmitter substance'. It was recognized t...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1997
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)89295-3